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Publikationen

2015

Imbalance of dendritic cell co-stimulation in COPD.
Stoll P, Ulrich M, Bratke K, Garbe K, Virchow JC and Lommatzsch M
Respiratory Research 2015, 16:19, doi:10.1186/s12931-015-0174-x

2014

Severe asthma: definition, diagnosis and treatment.
Lommatzsch M, Virchow JC.

Dtsch Arztebl Int. 2014 Dec 12;111(50):847-55. doi: 10.3238/arztebl.2014.0847.

Platelets in asthma: does size matter?
Stoll P
Lommatzsch M.
Respiration. 2014;88(1):22-3. doi: 10.1159/000362798.

Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD.
Stoll P
, Heinz AS, Bratke K, Bier A, Garbe K, Kuepper M, Virchow JC, Lommatzsch M.
Respir Res. 2014 Apr 18;15:48. doi: 10.1186/1465-9921-15-48 

Vitamin D binding protein and vitamin D in human allergen-induced endobronchial inflammation.
Bratke K, Wendt A, Garbe K, Kuepper M, Julius P, Lommatzsch M, Virchow JC
.
Clin Exp Immunol. 2014 Jul;177(1):366-72. doi: 10.1111/cei.12346.

[Health care of asthma patients in combination therapy with ICS and LABA - An analysis of statutory health insurance data].
Friedel H, Virchow JC.
Pneumologie. 2014 May;68(5):336-43. doi: 10.1055/s-0034-1365287. 

Randomized, double-blind phase II study to compare nitroglycerin plus oral vinorelbine plus cisplatin with oral vinorelbine plus cisplatin alone in patients with stage IIIB/IV non-small cell lung cancer (NSCLC).
Reinmuth N, Meyer A, Hartwigsen D, Schaeper C, Huebner G, Skock-Lober R, Bier A, Gerecke U, Held CP, Reck M.
Lung Cancer. 2014 Mar;83(3):363-8. doi: 10.1016/j.lungcan.2014.01.001. 

Eosinophilic esophagitis: asthma of the esophagus?
Virchow JC.

Dig Dis. 2014;32(1-2):54-60. doi: 10.1159/000357010. 

IL-33 is a mediator rather than a trigger of the acute allergic response in humans.
Fux M, Pecaric-Petkovic T, Odermatt A, Hausmann OV, Lorentz A, Bischoff SC, Virchow JC, Dahinden CA.
Allergy. 2014 Feb;69(2):216-22. doi: 10.1111/all.12309. 

2013

Medical care for allergic disorders in Germany: a paradox.
Lommatzsch M
, Koschel D, Welte T.
Pneumologie. 2013 Dec;67(12):659-61. doi: 10.1055/s-0033-1359000. Epub 2013 Dec 9.

Allergic diseases: what is new?.
Lommatzsch M
.
Dtsch Med Wochenschr. 2013 Dec;138(49):2533-5. doi: 10.1055/s-0033-1349666. Epub 2013 Nov 26.

Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial.
Lommatzsch M, Kraeft U, Troebs L, Garbe K, Bier A, Stoll P, Klammt S, Kuepper M, Bratke K, Virchow JC
.
Respir Res. 2013 Oct 29;14:114. doi: 10.1186/1465-9921-14-114.

Prescription of inhalers in asthma and COPD: towards a rational, rapid and effective approach.
Dekhuijzen PN, Vincken W, Virchow JC, Roche N, Agusti A, Lavorini F, van Aalderen WM, Price D.
Respir Med. 2013 Dec;107(12):1817-21. doi: 10.1016/j.rmed.2013.09.013. Epub 2013 Sep 25.

Transient impact of omalizumab in pollen allergic patients undergoing specific immunotherapy.
Kopp MV, Hamelmann E, Bendiks M, Zielen S, Kamin W, Bergmann KC, Klein C, Wahn U et al.; DUAL study group.
Pediatr Allergy Immunol. 2013 Aug;24(5):427-33. doi: 10.1111/pai.12098. Epub 2013 Jun 25.

Against all odds: anti-IgE for intrinsic asthma?
Lommatzsch M
, Korn S, Buhl R, Virchow JC.
Thorax. 2013 May 24. doi: 10.1136/thoraxjnl-2013-203738. [Epub ahead of print]

Clinically Relevant Effect of a New Intranasal Therapy (MP29-02) in Allergic Rhinitis Assessed by Responder Analysis.
Meltzer E, Ratner P, Bachert C, Carr W, Berger W, Canonica GW, Hadley J, Lieberman P, Hampel FC, Mullol J, Munzel U, Price D, Scadding G, Virchow JC, Wahn U, Murray R, Bousquet J.
Int Arch Allergy Immunol. 2013 May 4;161(4):369-377. [Epub ahead of print]

Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment.
Bratke K, Prieschenk C, Garbe K, Kuepper M, Lommatzsch M, Virchow JC
.
Clin Exp Allergy. 2013 Mar;43(3):312-21. doi: 10.1111/cea.12064.

Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation.
Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Vieira RP, Ayata K, Cicko S, Sorichter S, Walther DJ, Virchow JC, Taube C, Idzko M.
Am J Respir Crit Care Med. 2013 Mar 1;187(5):476-85. doi: 10.1164/rccm.201208-1440OC. Epub 2013 Jan 17.

2012

Stage-dependent association of BDNF and TGF-beta1 with lung function in stable COPD.
Stoll P, Wuertemberger U, Bratke K, Zingler C, Virchow CJLommatzsch M.
Respir Res. 2012 Dec 17;13(1):116. [Epub ahead of print]

Airway hyperresponsiveness: new insights into the pathogenesis.
Lommatzsch M.
Semin Respir Crit Care Med. 2012 Dec;33(6):579-87. doi: 10.1055/s-0032-1325617. Epub 2012 Oct 9.

Expression analysis and specific blockade of the receptor for human thymic stromal lymphopoietin (TSLP) by novel antibodies to the human TSLPRα receptor chain.
Borowski A, Vetter T, Kuepper M, Wohlmann A, Krause S, Lorenzen T, Virchow JC, Luttmann W, Friedrich K.
Cytokine. 2012 Nov 28. doi:pii: S1043-4666(12)00760-0. 10.1016/j.cyto.2012.10.025

EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy.
Calderon MA, Demoly P, Gerth van Wijk R, Bousquet J, Sheikh A, Frew A, Scadding G, Bachert C, Malling HJ, Valenta R, Bilo B, Nieto A, Akdis C, Just J, Vidal C, Varga EM, Alvarez-Cuesta E, Bohle B, Bufe A, Canonica WG, Cardona V, Dahl R, Didier A, Durham SR, Eng P, Fernandez-Rivas M, Jacobsen L, Jutel M, Kleine-Tebbe J, Klimek L, Lötvall J, Moreno C, Mosges R, Muraro A, Niggemann B, Pajno G, Passalacqua G, Pfaar O, Rak S, Senna G, Senti G, Valovirta E, van Hage M, Virchow JC, Wahn U, Papadopoulos N.
Clin Transl Allergy. 2012 Oct 30;2(1):20. doi: 10.1186/2045-7022-2-20.

Asthma and pregnancy
Virchow JC.
Semin Respir Crit Care Med. 2012 Dec;33(6):630-44. doi: 10.1055/s-0032-1326961. Epub 2012 Oct 9. 

Asthma.
Virchow JC, Barnes PJ.
Semin Respir Crit Care Med. 2012 Dec;33(6):577-8. doi: 10.1055/s-0032-1326958. Epub 2012 Oct 9

Topotecan/Cisplatin Compared with Cisplatin/Etoposide as First-Line Treatment for Patients with Extensive Disease Small-Cell Lung Cancer: Final Results of a Randomized Phase III Trial.
Fink TH, Huber RM, Heigener DF, Eschbach C, Waller C, Steinhauer EU, Virchow JC, Eberhardt F, Schweisfurth H, Schroeder M, Ittel T, Hummler S, Banik N, Bogenrieder T, Acker T, Wolf M.
J Thorac Oncol. 2012 Sep;7(9):1432-1439.

Untangling asthma phenotypes and endotypes.
Agache I, Akdis C, Jutel M, Virchow JC.
Allergy. 2012 Jul;67(7):835-46. 

Plasmacytoid dendritic cells and their Toll-like receptor 9 expression selectively decrease with age.
Garbe K, Bratke K, Wagner S, Virchow JC, Lommatzsch M.
Human Immunology. 2012 Feb 16. [Epub ahead of print] 

Emergency checklist: asthma attack.
Virchow JC.
MMW Fortschritte der Medizin. 2012 Feb 9;154(2):55-6.

Hypertrophic Pulmonary Osteoarthropathy as a Cue for NSCLC: Four Cases in the Light of the Current Literature.
Lommatzsch M, Julius P, Lueck W, Bier A, Virchow JC.
Pneumologie. 2012 Jan 16. [Epub ahead of print] German.

2011

Inhaled Corticosteroid/Long-Acting beta2-Agonist Combination Therapy for Asthma: Attitudes of Specialists in Europe.
Bousquet J, Winchester C, Papi A, Virchow JC, Haughney J, Costa D, Usmani O, Bjermer L, Price D.
International Archives of Allergy and Immunology 2011 Nov 1;157(3):303-310. [Epub ahead of print]

Bronchoconstriction and airway remodeling
Lommatzsch M, Kummer W, Virchow JC.
New England Journal Medicine. 2011 Sep 22;365(12):1156; author reply 1157. No abstract available.

Cough management: a practical approach
De Blasio F, Virchow JC, Polverino M, Zanasi A, Behrakis P, Kilinc G, Balsamo R, De Danieli G, Lanata L.
Cough. 2011 Oct 10;7(1):7. [Epub ahead of print]

Differential effect of clopidogrel and aspirin on the release of BDNF from platelets.
Stoll P, Plessow A, Bratke K, Virchow JC, Lommatzsch M.
Journal of Neuroimmunology. 2011 Jul 29. [Epub ahead of print]

Altered Phenotype of Blood Dendritic Cells in Patients with Acute Pneumonia.
Dreschler K, Bratke K, Petermann S, Thamm P, Kuepper M, Virchow JC, Lommatzsch M.
Respiration. 2011 Jun 16. [Epub ahead of print]

Inhaler devices for asthma: a call for action in a neglected field.
Papi A, Haughney J, Virchow JC, Roche N, Palkonen S, Price D.
European Respiratory Journal. 2011 May;37(5):982-5. No abstract available. 

Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation.
Vieira RP, Müller T, Grimm M, von Gernler V, Vetter B, Dürk T, Cicko S, Ayata CK, Sorichter S, Robaye B, Zeiser R, Ferrari D, Kirschbaum A, Zissel G, Virchow JC, Boeynaems JM, Idzko M.
American Journal of Respiratory Cell & Molecular Biology. 2011 Jul 15;184(2):215-23. Epub 2011 Apr 21.

Impact of ocular symptoms on quality of life (QoL), work productivity and resource utilisation in allergic rhinitis patients - an observational, cross sectional study in four countries in Europe.
Virchow JC, Kay S, Demoly P, Mullol J, Canonica W, Higgins V.
Journal of Medical Economics. 2011 Apr 14. [Epub ahead of print]

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma.
Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis E Souza C, Hammad H, Lambrecht BN.
Immunity. 2011 Apr 5. [Epub ahead of print]

Tiotropium step-up therapy in asthma.
Lommatzsch M, Julius P, Virchow J
New England Journal of Medicine. 2011 Feb 10;364(6):578; author reply 578-9

Impact of immunotherapy on blood dendritic cells in patients with Hymenoptera venom allergy.
Dreschler K, Bratke K, Petermann S, Bier A, Thamm P, Kuepper M, Virchow JC, Lommatzsch M
Journal of Allergy & Clinical Immunology. 2011 Feb;127(2):487-494.e1-3.

Pharmacoeconomics in COPD and inappropriateness of diagnostics, management and treatment.
Donner CF, Virchow JC, Lusuardi M
Respiratory Medicine. 2011 Jan 12. [Epub ahead of print] 

Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus.
Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow JC
Allergy. 2011 Mar;66(3):386-95.

bis 2010

2010

Development and implementation of guidelines in allergic rhinitis - an ARIA-GA2LEN paper.
Bousquet J, Schünemann HJ, Zuberbier T, Bachert C, Baena-Cagnani CE, Bousquet PJ, Brozek J, Canonica GW, Casale TB, Demoly P, Gerth van Wijk R, Ohta K, Bateman ED, Calderon M, Cruz AA, Dolen WK, Haughney J, Lockey RF, Lötvall J, O'Byrne P, Spranger O, Togias A, Bonini S, Boulet LP, Camargos P, Carlsen KH, Chavannes NH, Delgado L, Durham SR, Fokkens WJ, Fonseca J, Haahtela T, Kalayci O, Kowalski ML, Larenas-Linnemann D, Li J, Mohammad Y, Mullol J, Naclerio R, O'Hehir RE, Papadopoulos N, Passalacqua G, Rabe KF, Pawankar R, Ryan D, Samolinski B, Simons FE, Valovirta E, Yorgancioglu A, Yusuf OM, Agache I, Ait-Khaled N, Annesi-Maesano I, Beghe B, Ben Kheder A, Blaiss MS, Boakye DA, Bouchard J, Burney PG, Busse WW, Chan-Yeung M, Chen Y, Chuchalin AG, Costa DJ, Custovic A, Dahl R, Denburg J, Douagui H, Emuzyte R, Grouse L, Humbert M, Jackson C, Johnston SL, Kaliner MA, Keith PK, Kim YY, Klossek JM, Kuna P, Le LT, Lemiere C, Lipworth B, Mahboub B, Malo JL, Marshall GD, Mavale-Manuel S, Meltzer EO, Morais-Almeida M, Motala C, Naspitz C, Nekam K, Niggemann B, Nizankowska-Mogilnicka E, Okamoto Y, Orru MP, Ouedraogo S, Palkonen S, Popov TA, Price D, Rosado-Pinto J, Scadding GK, Sooronbaev TM, Stoloff SW, Toskala E, van Cauwenberge P, Vandenplas O, van Weel C, Viegi G, Virchow JC, Wang DY, Wickman M, Williams D, Yawn BP, Zar HJ, Zernotti M, Zhong N; In collaboration with the WHO Collaborating Center of Asthma and Rhinitis (Montpellier).
Allergy. 2010 Oct;65(10):1212-21

The purinergic receptor P2Y(2) receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation.
Müller T, Robaye B, Vieira RP, Ferrari D, Grimm M, Jakob T, Martin SF, Di Virgilio F, Boeynaems JM, Virchow JC, Idzko M.
Allergy. 2010 Sep 29. [Epub ahead of print]

A subgroup analysis of the MONICA study: A 12-month, open-label study of add-on montelukast treatment in asthma patients.
Virchow JC, Mehta A, Ljungblad L, Mitfessel H.
J Asthma. 2010 Sep 22. [Epub ahead of print]

[Asthma - historical development, current status and perspectives]
Virchow JC.
Pneumologie. 2010 Sep;64(9):541-9.

[Aspirin-Intolerance-Syndrom : a common and interdisciplinary disease]
Umbreit C, Virchow JC, Thorn C, Hörrmann K, Klimek L, Pfaar O.
Internist (Berl). 2010 Sep;51(9):1196-8, 1200-1. German.

Cicko S, Lucattelli M, Müller T, Lommatzsch M, De Cunto G, Cardini S, Sundas W, Grimm M, Zeiser R, Dürk T, Zissel G, Boeynaems JM, Sorichter S, Ferrari D, Di Virgilio F, Virchow JC, Lungarella G, Idzko M.
Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema.
Journal of Immunology. 2010 Jul 1;185(1):688-97

Lucattelli M, Cicko S, Müller T, Lommatzsch M, de Cunto G, Cardini S, Sundas W, Grimm M, Zeiser R, Dürk T, Zissel G, Sorichter S, Ferrari D, di Virgilio F, Virchow JC, Lungarella G, Idzko M.
P2X7 Receptor Signalling in the Pathogenesis of Smoke-induced Lung Inflammation and Emphysema.
American Journal of Respiratory Cell & Molecular Biology. 2010 May 27. [Epub ahead of print]

Haughney J, Price D, Barnes NC, Virchow JC, Roche N, Chrystyn H.
Choosing inhaler devices for people with asthma: Current knowledge and outstanding research needs.
Respiratory Medicine. 2010 May 14. [Epub ahead of print] 

Bratke K, Nielsen J, Manig F, Klein C, Kuepper M, Geyer S, Julius P, Lommatzsch M, Virchow JC.
Functional expression of granzyme B in human plasmacytoid dendritic cells: a role in allergic inflammation.
Clinical & Experimental Allergy. 2010 Apr 13 

Julius P, Grosse-Thie C, Kuepper M, Bratke K, Virchow JC.
sCD14 in bronchoalveolar lavage 18, 42 and 162 hours after segmental allergen provocation.
Scandinavian Journal of Immunology. 2010 Apr;71(4):304-11

Lommatzsch M, Cicko S, Müller T, Lucattelli M, Bratke K, Stoll P, Grimm M, Dürk T, Zissel G, Ferrari D, Di Virgilio F, Sorichter S, Lungarella G, Virchow JC, Idzko M.
Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease.
American Journal of Respiratory & Critical Care Medicine. 2010 May 1;181(9):928-34

2009

Virchow C.
[Are there any advantages of a fixed combination in the treatment of asthma with respect to safety and tolerability?]
Deutsche Medizinische Wochenschrift. 2009 Dec;134 Suppl 10:S376-80. Epub 2009 Nov 25. Review.

Virchow JC, Mehta A, Ljungblad L, Mitfessel H; the MONICA study group.
Add-on montelukast in inadequately controlled asthma patients: A 6-month open-label study.
Respir Med. 2010 May;104(5):644-51.

Virchow JC.
[Asthma--a small airway disease: concepts and evidence]
Pneumologie. 2009 Dec;63 Suppl 2:S96-101. 

Brusasco V, Dinh-Xuan AT, Leff AR, Adler KB, Glenny RW, Dempsey JA, Levy ML, Panettieri R, Reddel HK, Singh D, Virchow JC.
Impact factor and its role in academic promotion.
Eur Respir J. 2009 Dec;34(6):1499-500. 

Lommatzsch M, Bratke K, Knappe T, Bier A, Dreschler K, Kuepper M, Stoll P, Julius P, Virchow JC.
Acute effects of tobacco smoke on human airway dendritic cells in vivo.
European Respiratory Journal. 2009 Sep 9. [Epub ahead of print]

Hasford J, Uricher J, Tauscher M, Bramlage P, Virchow JC.
Persistence with asthma treatment is low in Germany especially for controller medication - a population based study of 483 051 patients.
Allergy. 2009 Aug 27.

Stoll P, Virchow JC, Lommatzsch M.
Postpartum venous thromboembolism.
New England Journal of Medicine. 2009 Apr 9;360(15):1574.

Bratke K, Kuepper M, Julius P, Lommatzsch M, Virchow JC.
Thrombomodulin- A novel player in allergic asthma.
Journal of Allergy & Clinical Immunology. 2009 Feb 27. [Epub ahead of print] 

Lommatzsch M, Lindner Y, Edner A, Bratke K, Kuepper M, Virchow JC.
Adverse effects of salmeterol in asthma- a neuronal perspective.
Thorax. 2009 Feb 22. [Epub ahead of print]

Kopp MV, Hamelmann E, Zielen S, Kamin W, Bergmann KC, Sieder C, Stenglein S, Seyfried S, Wahn U; DUAL study group.
Collaborators: Kopp MV, Volksbeck UL, Grychtol R, Lange J, Hamelmann E, Wahn U, Stock P, Parasher K, Bergmann KC, Worm M, Hae-Hyuk L, Zielen S, Schulze J, Schauer U, Rothoeft T, Kamin W, Sahin G, Klr-Hlawatsch B, Brehler R, Hemfort P, Beeh KM, Beier J, Kunkel G, Herold D, Kleine-Tebbe J, Virchow JC, Bier A, Stoll P, Steinmetz KO, Lessing U, Kornmann O, Eich A, Deckelmann R, Eckardt G, Klimek L, Pfaar O, Lindemann L, Wild S, Ern G, Feussner W, Debertin A, Peslis N, Balzer R, Zingler D, Wehrmann D, Volgmann L.
Combination of omalizumab and specific immunotherapy is superior to immunotherapy in patients with seasonal allergic rhinoconjunctivitis and co-morbid seasonal allergic asthma.
Clinical & Experimental Allergy. 2009 Feb;39(2):271-9. Epub 2008 Oct 30

2008

Julius P, Virchow JC
Reply to: Repeated Segmental Allergen Provocation: Reassessment of Provocation Dose
Journal of Allergy & Clinical Immunology 2008 Dec 3. [Epub ahead of print]

Bratke K, Goettsching H, Kuepper M, Geyer S, Luttmann W, Virchow JC
Interleukin-4 suppresses the cytotoxic potential of in vitro generated, adaptive regulatory CD4+ T cells by downregulation of granzyme B
Immunology 2008 Dec 23. [Epub ahead of print]

Luttmann W, Bratke K, Küpper M, Myrtek D
Der Experimentator - Immunologie
3. Auflage, Oktober 2008
Spektrum Akademischer Verlag, Heidelberg

Sebastian K, Borowski A, Kuepper M, Friedrich K.
Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma.
Cell Communication and Signaling: CCS. 2008 Aug 25;6

Myrtek D, Müller T, Geyer V, Derr N, Ferrari D, Zissel G, Dürk T, Sorichter S, Luttmann W, Kuepper M, Norgauer J, Di Virgilio F, Virchow JC Jr, Idzko M.
Activation of human alveolar macrophages via P2 receptors: coupling to intracellular Ca2+ increases and cytokine secretion.
Journal of Immunology. 2008 Aug 1;181(3):2181-8.

Bratke K, Klug A, Julius P, Kuepper M, Lommatzsch M, Sparmann G, Luttmann W, Virchow JC.
Granzyme K: a novel mediator in acute airway inflammation.
Thorax. 2008 Nov;63(11). Epub 2008 Jun 17

Kuepper M, Bratke K, Virchow JC.
Chitinase-like Protein and Asthma
New England Journal of Medicine. 2008 Mar 6;358(10); author reply 1073-75

Borowski A, Kuepper M, Horn U, Knüpfer U, Zissel G, Höhne K, Luttmann W, Krause S, Virchow JC Jr, Friedrich K.
Interleukin-13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts.
Clinical & Experimental Allergy. 2008 Apr;38(4):619-28. 

Virchow JC.
Prevention of respiratory tract diseases.
Internist (Berl). 2008 Feb;49(2):170-7.

Julius P, Lommatzsch M, Kuepper M, Bratke K, Faehndrich S, Luttmann W, Virchow JC.
Safety of segmental allergen challenge in human allergic asthma.
Journal of Allergy & Clinical Immunology. 2008 Mar;121(3):712-7. Epub 2007 Oct 29.

Semrau S, Klautke G, Virchow JC, Kundt G, Fietkau R.
Impact of comorbidity and age on the outcome of patients with inoperable NSCLC treated with concurrent chemoradiotherapy.
Respiratory Medicine. 2008 Feb;102(2):210-8. Epub 2007 Nov 5

Bratke K, Klug M, Bier A, Julius P, Kuepper M, Virchow JC, Lommatzsch M.
Function-associated Surface Molecules on Airway Dendritic Cells in Cigarette Smokers.
American Journal of Respiratory Cell & Molecular Biology. 2008 Jun;38(6):655-60.

Virchow C.
[Tuberculosis and art]
Pneumologie. 2008 Jan;62(1):55; author reply 55-6.

Virchow JC, Crompton GK, Dal Negro R, Pedersen S, Magnan A, Seidenberg J, Barnes PJ.
Importance of inhaler devices in the management of airway disease.
Respiratory Medicine. 2008 Jan;102(1):10-9. Epub 2007 Oct 17

2007

Canonica GW, Bousquet J, Mullol J, Scadding GK, Virchow JC.
A survey of the burden of allergic rhinitis in Europe.
Allergy. 2007;62 Suppl 85:17-25

Bier A, Virchow JC
Verträglichkeit und Wirksamkeit einer 3-tägigen Rush-Hyposensibilisierung bei Bienen- und Wespengiftallergie.
Allergologie 4, 2007, 125-128

Bratke K, Maruschke L, Darowski M, Kuepper M, Braun A, Virchow JC, Lommatzsch M.
A role for the neurotrophin receptor TrkB on maturing dendritic cells.
Journal of Neuroimmunology. 2007 Sep;189(1-2):88-94. Epub 2007 Aug 15 

Bratke K, Julius P, Virchow JC.
Invariant natural killer T cells in obstructive pulmonary diseases.
New England Journal of Medicine. 2007 Jul 12;357(2):194; author reply 194-5

Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MA, Muskens F, Hoogsteden HC, Luttmann W, Ferrari D, Di Virgilio F, Virchow JC Jr, Lambrecht BN.
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.
Nature Medicine. 2007 Aug;13(8):913-9

Lommatzsch M, Bratke K, Bier A, Julius P, Kuepper M, Luttmann W, Virchow JC.
Airway dendritic cell phenotypes in inflammatory diseases of the human lung.
European Respiratory Journal. 2007 Nov;30(5):878-86. 

Roesner D, Virchow JC.
[Basic diagnostic approach to suspected allergic asthma]
MMW Fortschritte der Medizin. 2007 Feb 15;149(7):36-8, 40

Horne R, Price D, Cleland J, Costa R, Covey D, Gruffydd-Jones K, Haughney J, Henrichsen SH, Kaplan A, Langhammer A, Ostrem A, Thomas M, van der Molen T, Virchow JC, Williams S.
Can asthma control be improved by understanding the patient's perspective?
BMC Pulmonary Medicine. 2007 May 22;7:8

Bratke K, Krieghoff L, Kuepper M, Luttmann W, Virchow JC.
CD8+ T cell activation and differentiation in allergic asthma and the impact of cytomegalovirus serological status.
Clinical & Experimental Immunology. 2007 Aug;149(2):311-6 

Knackmuss S, Krause S, Engel K, Reusch U, Virchow JC, Mueller T, Kraich M, Little M, Luttmann W, Friedrich K.
Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain.
Journal of Biological Chemistry. 2007 Mar;388(3):325-30 

Lommatzsch M, Niewerth A, Klotz J, Schulte-Herbruggen O, Zingler C, Schuff-Werner P, Virchow JC.
Platelet and plasma BDNF in lower respiratory tract infections of the adult.
Respiratory Medicine. 2007 Jul;101(7):1493-9

Lommatzsch M, Julius P, Virchow JC.
Mice running late: T-cell kinetics in models of asthma.
American Journal of Respiratory & Critical Care Medicine. 2007 Mar 1;175(5):522b-523

Diamant Z, Boot JD, Virchow JC.
Summing up 100 years of asthma.
Respiratory Medicine. 2007 Mar;101(3):378-88

Gillissen A, Berdel D, Buhl R, Criee CP, Kardos P, Magnussen H, Rabe KF, Rolke M, Vogelmeier C, Worth H, Virchow JC.
[beta(2)-Sympathomimetics: risks for asthma therapy? Lessons from the SMART1 Study. A statement from the German Respiratory Tract League]
Deutsche Medizinische Wochenschrift. 2007 Jan 5;132(1-2):33-9 

Schulte-Herbruggen O, Litzke J, Hornych K, Zingler C, Hoppner J, Virchow JC, Hellweg R, Lommatzsch M.
Maternal nerve growth factor serum levels in the perinatal period.
Journal of Reproductive Immunology. 2007 Jun;74(1-2):170-3

Bratke K, Lommatzsch M, Julius P, Kuepper M, Kleine HD, Luttmann W, Christian Virchow J.
Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge.
Thorax. 2007 Feb;62(2):168-75

Semrau S, Bier A, Thierbach U, Virchow C, Ketterer P, Klautke G, Fietkau R.
6-year experience of concurrent radiochemotherapy with vinorelbine plus a platinum compound in multimorbid or aged patients with inoperable non-small cell lung cancer.
Strahlentherapie & Onkologie. 2007 Jan;183(1):30-5

Lommatzsch M, Virchow JC.
The neural underpinnings of asthma.
Journal of Allergy & Clinical Immunology. 2007 Jan;119(1):254-5

2006

Hasford J, Virchow JC.
Excess mortality in patients with asthma on long-acting beta2-agonists.
European Respiratory Journal. 2006 Nov;28(5):900-2

Schuette W, Blankenburg T, Schneider CP, von Weikersthal LF, Guetz S, Laier-Groeneveld G, Virchow JC, Chemaissani A, Reck M.
Randomized, multicenter, open-label phase II study of gemcitabine plus single-dose versus split-dose carboplatin in the treatment of patients with advanced-stage non-small-cell lung cancer.
Clinical Lung Cancer. 2006 Sep;8(2):135-9.

Bratke K, Haupt F, Kuepper M, Bade B, Faehndrich S, Luttmann W, Virchow JC Jr.
Decrease of cytotoxic T cells in allergic asthma correlates with total serum immunglobulin E.
Allergy. 2006 Nov;61(11):1351-7

Lommatzsch M, Julius P, Kuepper M, Garn H, Bratke K, Irmscher S, Luttmann W, Renz H, Braun A, Virchow JC.
The course of allergen-induced leukocyte infiltration in human and experimental asthma.
Journal of Allergy & Clinical Immunology. 2006 Jul;118(1):91-7

Tschopp CM, Spiegl N, Didichenko S, Luttmann W, Julius P, Virchow JC, Hack CE, Dahinden CA.
Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma.
Blood. 2006 Oct 1;108(7):2290-9

Kleinfeldt T, Rehders TC, Nienaber CA, Ince H, Schneider H, Virchow JC.
[Hematothorax after sudden chest pain]
Deutsche Medizinische Wochenschrift. 2006 Jun 9;131(23):1315-8

Lommatzsch M, Virchow JC.
Letter regarding article by Ejiri et al, "possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease".
Circulation. 2006 Apr 25;113(16):e724

Klautke G, Fähndrich S, Semrau S, Büscher C, Virchow C, Fietkau R.
Simultaneous chemoradiotherapy with irinotecan and cisplatin in limited disease small cell lung cancer: a phase I study.
Lung Cancer. 2006 Aug;53(2):183-8

Virchow JC, Bachert C.
Efficacy and safety of montelukast in adults with asthma and allergic rhinitis.
Respiratory Medicine. 2006 Nov;100(11):1952-9 

Virchow JC.
[Therapy-resistant asthma--a distinct phenotype?]
Medizinische Klinik (Munich). 2006 Apr 15;101(4):301-7

Nassenstein C, Mohring UH, Luttmann W, Virchow JC Jr, Braun A.
Differential expression of the neurotrophin receptors p75NTR, TrkA, TrkB and TrkC in human peripheral blood mononuclear cells.
Experimental & Toxicologic Pathology. 2006 Jun;57 Suppl 2:55-63

Bier A, Virchow JC.
[Pneumological disease in pregnancy]
MMW Fortschritte der Medizin. 2005 Apr 21;147(16):32-3, 35-6

Krause S, Behrends J, Borowski A, Lohrmann J, Lang S, Myrtek D, Lorenzen T, Virchow JC, Luttmann W, Friedrich K.
Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor alpha1.
Molecular Immunology. 2006 Apr;43(11):1799-807

Lommatzsch M, Hornych K, Zingler C, Schuff-Werner P, Hoppner J, Virchow JC.
Maternal serum concentrations of BDNF and depression in the perinatal period.
Psychoneuroendocrinology. 2006 Apr;31(3):388-94

2005

Virchow JC.
[On what criteria is the choice of an inhaler made for the treatment of asthma?]
Revue de Pneumologie Clinique. 2005 Sep;61(Spec no. 2):3S15-9

Bade B, Lohrmann J, ten Brinke A, Wolbink AM, Wolbink GJ, ten Berge IJ, Virchow JC Jr, Luttmann W, Hack CE.
Detection of soluble human granzyme K in vitro and in vivo.
European Journal of Immunology. 2005 Oct;35(10):2940- 

Bade B, Boettcher HE, Lohrmann J, Hink-Schauer C, Bratke K, Jenne DE, Virchow JC Jr, Luttmann W.
Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes.
International Immunology. 2005 Nov;17(11):1419-28

Schulte-Herbrüggen O, Nassenstein C, Lommatzsch M, Quarcoo D, Renz H, Braun A.
Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes.
Journal of Neuroimmunology. 2005 Mar;160(1-2):204-9 

Schuhmann B, Dietrich A, Sel S, Hahn C, Klingenspor M, Lommatzsch M, Gudermann T, Braun A, Renz H, Nockher WA.
A role for brain-derived neurotrophic factor in B cell development.
Journal of Neuroimmunology. 2005 Jun;163(1-2):15-23

Virchow JC.
What plays a role in the choice of inhaler device for asthma therapy?
Current Medical Research & Opinion. 2005;21 Suppl 4:S19-25

Muller T, Bayer H, Myrtek D, Ferrari D, Sorichter S, Ziegenhagen MW, Zissel G, Virchow JC Jr, Luttmann W, Norgauer J, Di Virgilio F, Idzko M.
The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion.
American Journal of Respiratory & Cell Molecular Biology. 2005 Dec;33(6):601-9

Bratke K, Kuepper M, Bade B, Virchow JC Jr, Luttmann W.
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.
European Journal of Immunology. 2005 Sep;35(9):2608-16

Windisch W, Kostic S, Dreher M, Virchow JC Jr, Sorichter S.
Outcome of patients with stable COPD receiving controlled noninvasive positive pressure ventilation aimed at a maximal reduction of Pa(CO2).
Chest. 2005 Aug;128(2):657-62

Staats R, Stoll P, Zingler D, Virchow JC, Lommatzsch M.
Regulation of brain-derived neurotrophic factor (BDNF) during sleep apnoea treatment.
Thorax. 2005 Aug;60(8):688-92

Lommatzsch M, Quarcoo D, Schulte-Herbruggen O, Weber H, Virchow JC, Renz H, Braun A.
Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood.
International Journal of Developmental Neuroscience. 2005 Oct;23(6):495-500

Kuepper M, Bratke K, Julius P, Ogawa K, Nagata K, Luttmann W, Virchow JC Jr.
Increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma.
Clinical & Expimental Allergy. 2005 May;35(5):643-9

Virchow JC.
Fluticasone reduces CRP in COPD.
American Journal of Respiratory & Critical Care Medicine. 2005 May 15;171(10):1191

Virchow JC.
[Asthma, allergic rhinitis, sinusitis. Concept of the "unified respiratory tracts"]
HNO. 2005 May;53 Suppl 1:S16-20

Windisch W, Storre JH, Sorichter S, Virchow JC Jr.
Comparison of volume- and pressure-limited NPPV at night: a prospective randomized cross-over trial.
Respiratory Medicine. 2005 Jan;99(1):52-9

Kallinich T, Schmidt S, Hamelmann E, Fischer A, Qin S, Luttmann W, Virchow JC, Kroczek RA.
Chemokine-receptor expression on T cells in lung compartments of challenged asthmatic patients.
Clinical & Expimental Allergy. 2005 Jan;35(1):26-33 

Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, Virchow JC.
The impact of age, weight and gender on BDNF levels in human platelets and plasma.
Neurobiology of Aging. 2005 Jan;26(1):115-23

Lommatzsch M, Schloetcke K, Klotz J, Schuhbaeck K, Zingler D, Zingler C, Schulte-Herbruggen O, Gill H, Schuff-Werner P, Virchow JC.
Brain-derived neurotrophic factor in platelets and airflow limitation in asthma.
American Journal of Respiratory & Critical Care Medicine. 2005 Jan 15;171(2):115-20

2004

Virchow JC.
Guidelines versus clinical practice--which therapy and which device?
Respiratory Medicine. 2004 Oct;98 Suppl B:S28-34

Virchow C.
[80 years "the magic mountain by Thomas Mann"]
Pneumologie. 2004 Nov;58(11):791-802

Kuepper M, Koester K, Bratke K, Myrtek D, Ogawa K, Nagata K, Virchow JC Jr, Luttmann W.
Increase in Ksp37-positive peripheral blood lymphocytes in mild extrinsic asthma.
Clinical & Expimental Immunology. 2004 Aug;137(2):359-65

Myrtek D, Knoll M, Matthiesen T, Krause S, Lohrmann J, Schillinger D, Idzko M, Virchow JC, Friedrich K, Luttmann W.
Expression of interleukin-13 receptor alpha 1-subunit on peripheral blood eosinophils is regulated by cytokines.
Immunology. 2004 Aug;112(4):597-604

Braun A, Lommatzsch M, Neuhaus-Steinmetz U, Quarcoo D, Glaab T, McGregor GP, Fischer A, Renz H.
Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation.
British Journal of Pharmacology. 2004 Feb;141(3):431-40

Quarcoo D, Schulte-Herbrüggen O, Lommatzsch M, Schierhorn K, Hoyle GW, Renz H, Braun A.
Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation.
Clinical & Expimental Allergy. 2004 Jul;34(7):1146-51 

Julius P, Hochheim D, Boser K, Schmidt S, Myrtek D, Bachert C, Luttmann W, Virchow JC.
Interleukin-5 receptors on human lung eosinophils after segmental allergen challenge.
Clinical & Expimental Allergy. 2004 Jul;34(7):1064-70

Lommatzsch M, Klotz J, Virchow JC Jr.
Postnatal dexamethasone for lung disease of prematurity.
New England Journal of Medicine. 2004 Jun 24;350(26):2715-8; author reply 2715-8 

Bratke K, Bottcher B, Leeder K, Schmidt S, Kupper M, Virchow JC Jr, Luttmann W.
Increase in granzyme B+ lymphocytes and soluble granzyme B in bronchoalveolar lavage of allergen challenged patients with atopic asthma.
Clinical & Expimental Immunology. 2004 Jun;136(3):542-8

Prasse A, Muller KM, Kurz C, Hamm H, Virchow JC Jr.
Does interferon-gamma improve pulmonary function in idiopathic pulmonary fibrosis?
European Respiratory Journal. 2003 Dec;22(6):906-11 

2003

 Semrau S, Bier A, Thierbach U, Virchow C, Ketterer P, Fietkau R.
Concurrent radiochemotherapy with vinorelbine plus cisplatin or carboplatin in patients with locally advanced non-small-cell lung cancer (NSCLC) and an increased risk of treatment complications. Preliminary results.
Strahlentherapie & Onkologie. 2003 Dec;179(12):823-31

Idzko M, Panther E, Bremer HC, Sorichter S, Luttmann W, Virchow CJ Jr, Di Virgilio F, Herouy Y, Norgauer J, Ferrari D.
Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils.
British Journal of Pharmacology. 2003 Apr;138(7):1244-50

Lommatzsch M, Braun A, Renz H.
Neurotrophins in allergic airway dysfunction: what the mouse model is teaching us.
Annals of the New York Academy of Sciences. 2003 May;992:241-9

Virchow JC.
[Fix combinations should be first line therapy in asthma irrespective of its severity - contra]
Pneumologie. 2003 Nov;57(11):677-80

Gillessen A, Virchow JC.
[Gastroesophageal reflux disease (GERD) and asthma]
Deutsche Medizinische Wochenschrift. 2003 Nov 14;128(46):2427-30 

Nassenstein C, Braun A, Erpenbeck VJ, Lommatzsch M, Schmidt S, Krug N, Luttmann W, Renz H, Virchow JC Jr.
The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma.
Journal of Experimental Medicine. 2003 Aug 4;198(3):455-67

Gillissen A, Bergmann KC, Kleine-Tebbe J, Schultze-Werninghaus G, Virchow JC Jr, Wahn U, Graf von der Schulenburg JM.
[Specific immunotherapy in allergic asthma
Deutsche Medizinische Wochenschrift. 2003 Jan 31;128(5):204-9

2002 

Windisch W, Storre JH, Matthys H, Sorichter S, Virchow JC Jr.
Weaning from mechanical ventilation by long-term nasal positive pressure ventilation in two patients with acute respiratory distress syndrome associated with pneumococcal sepsis.
Respiration. 2002;69(5):464-7

Windisch W, Vogel M, Sorichter S, Hennings E, Bremer H, Hamm H, Matthys H, Virchow JC Jr.
Normocapnia during nIPPV in chronic hypercapnic COPD reduces subsequent spontaneous PaCO2
Respiratory Medicine. 2002 Aug;96(8):572-9 

Rose EC, Staats R, Virchow C Jr, Jonas IE.
Occlusal and skeletal effects of an oral appliance in the treatment of obstructive sleep apnea.
Chest. 2002 Sep;122(3):871-7

Rose E, Staats R, Virchow C, Jonas IE.
A comparative study of two mandibular advancement appliances for the treatment of obstructive sleep apnoea.
European journal of orthodontics. 2002 Apr;24(2):191-8

Hauck RW, Virchow JC.
[Anti-obstructive anti-inflammatory therapy: no problems in pneumology, problematic in cardiology?]
Medizinische Klinik (Munich). 2002 Jun 15;97(6):350-6 

Virchow JC.
Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy.
Chest. 2002 Jun;121(6):2083-4

2001

Biller H, Bade B, Matthys H, Luttmann W, Virchow JC.
Interferon-gamma secretion of peripheral blood CD8+ T lymphocytes in patients with bronchial asthma: in vitro stimulus determines cytokine production.
Clinical & Expimental Immunology. 2001 Nov;126(2):199-205

Weissflog D, Matthys H, Virchow JC Jr.
[Epidemiology and costs of bronchial asthma and chronic bronchitis in Germany]
Deutsche Medizinische Wochenschrift. 2001 Jul 13;126(28-29):803-8 

Braun A, Quarcoo D, Schulte-Herbrüggen O, Lommatzsch M, Hoyle G, Renz H.
Nerve growth factor induces airway hyperresponsiveness in mice.
International archives of allergy and immunology. 2001 Jan-Mar;124(1-3):205-7. 

Idzko M, Dichmann S, Panther E, Ferrari D, Herouy Y, Virchow C Jr, Luttmann W, Di Virgilio F, Norgauer J.
Functional characterization of P2Y and P2X receptors in human eosinophils.
Journal of cellular Physiology. 2001 Sep;188(3):329-36 

Virchow JC.
Drug-induced bronchospasm--a negligible phenomenon?
Respiration. 2001;68(4):343-4

Virchow JC Jr, Faehndrich S, Nassenstein C, Bock S, Matthys H, Luttmann W.
Effect of a specific cysteinyl leukotriene-receptor 1-antagonist (montelukast) on the transmigration of eosinophils across human umbilical vein endothelial cells
Clinical & Experimental Allergy. 2001 Jun;31(6):836-44

Ness T, Virchow JC.
[Posterior uveitis: sarcoidosis or tuberculosis]
Ophthalmologe. 2001 Feb;98(2):207-11 

2000 

Arnold V, Balkow S, Staats R, Matthys H, Luttmann W, Virchow JC Jr.
[Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma]
Pneumologie. 2000 Oct;54(10):468-7

Prasse A, Georges CG, Biller H, Hamm H, Matthys H, Luttmann W, Virchow JC Jr.
Th1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4+ and CD8+ T cells.
Clinical & Expimental Immunology. 2000 Nov;122(2):241-8

Neuhaus-Steinmetz U, Glaab T, Daser A, Braun A, Lommatzsch M, Herz U, Kips J, Alarie Y, Renz H.
Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation.
International archives of allergy and immunology. 2000 Jan;121(1):57-67

Braun A, Lommatzsch M, Renz H.
The role of neurotrophins in allergic bronchial asthma.
Clinical & Experimental Allergy. 2000 Feb;30(2):178-86

Ferrari D, Idzko M, Dichmann S, Purlis D, Virchow C, Norgauer J, Chiozzi P, Di Virgilio F, Luttmann W.
P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production.
FEBS Lett. 2000 Dec 15;486(3):217-24

Dichmann S, Idzko M, Zimpfer U, Hofmann C, Ferrari D, Luttmann W, Virchow C Jr, Di Virgilio F, Norgauer J.
Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils.
Blood. 2000 Feb 1;95(3):973-8

Virchow JC Jr, Prasse A, Naya I, Summerton L, Harris A.
Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids.
American Journal of Respiratory & Critical Care Medicine. 2000 Aug;162(2 Pt 1):578-85

Staats R, Balkow S, Sorichter S, Northoff H, Matthys H, Luttmann W, Berg A, Virchow JC.
Change in perforin-positive peripheral blood lymphocyte (PBL) subpopulations following exercise.
Clinical & Expimental Immunology. 2000 Jun;120(3):434-9 

Luttmann W, Dauer E, Schmidt S, Marx O, Hossfeld M, Matthys H, Virchow JC Jr.
Effects of interferon-gamma and tumour necrosis factor-alpha on CD95/Fas ligand-mediated apoptosis in human blood eosinophils.
Scandinavian Journal of Immunology. 2000 Jan;51(1):54-9

Arnold V, Balkow S, Staats R, Matthys H, Luttmann W, Virchow JC Jr.
Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma.
American Journal of Respiratory & Critical Care Medicine. 2000 Jan;161(1):182-6